Ashraf Mohieldin, PhD

Master of Pharmaceutical Sciences
Assistant Professor of Molecular Biology and Biochemistry

Phone: (916) 686-8558
Fax: (916) 686-8142
Ashraf.Mohieldin@cnsu.edu

About

Dr. Mohieldin obtained his bachelor's degree in Pharmacy and Pharmaceutical sciences with departmental honor from the University of Toledo in 2011. He received his Ph.D. in Medicinal and Biological Chemistry from the University of Toledo in 2015. During his Ph.D., he received the prestigious NIH-F31 fellowship award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). He completed his fellowship at Chapman University and later was promoted to a research associate professor. In 2022, he joined the California Northstate University as an assistant professor.

Research Interest

Dr. Mohieldin's research focuses on the physiological role of cilia and ciliary extracellular vesicles, which have been linked to a wide range of diseases, termed ciliopathy disorders, including polycystic kidney disease, cardiovascular diseases, and neurodegenerative disorders. His laboratory utilizes a variety of in vitro and in vivo disease models, including patient tissue and blood samples, genetically modified cell lines, and transgenic mouse models.

With established expertise and publishing records in extracellular vesicles and cilia biology, his work is evolving to lead the efforts to investigate ciliopathy-associated cardiovascular diseases. In addition to the new classification of ciliary vesicles (ciEVs), his studies indicated that low circulation of extracellular vesicles results in hypotension with compensated heart function, left ventricular hypertrophy, cardiac fibrosis, and arrhythmogenic characteristics, which result in a high mortality rate in the ciliopathy-associated cardiovascular diseases mouse model.

In particular, his work has provided a tremendous scientific impact (Adv Sci, 2020 and J Extracell Vesicles. 2021), and he intends to be productive moving forward to advance our knowledge and rejuvenate our therapeutic approach toward ciliopathy-associated cardiovascular diseases.

Publication

For the list of Publications, please visit: