Faculty

Faculty Profiles

Ahmed El-Shamy, PhDAhmed El-Shamy, PhD

Assistant Professor-Virology
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Phone: (916) 686-7300

 

Dr. Ahmed El-Shamy is an assistant professor of Virology at California Northstate University. In 2009, Dr. El-Shamy received a PhD in Molecular Virology from Kobe University, Japan. His PhD study was selected as the Medical School Excellent Paper for the 2008-2009 Academic Year. In 2011, Dr. El-Shamy joined Division of Liver Diseases at Mount Sinai School of Medicine, New York as a senior post-doctoral fellow. Dr. El-Shamy received 2014 Japan Society for the Promotion of Science (JSPS) Award; and 2013 Encouragement State Prize in Medical Sciences from the Academy of Scientific Research and Technology, Egypt. Dr. El-Shamy published 26 publications in high impact peer-viewed journal (https://www.ncbi.nlm.nih.gov/pubmed/?term=Ahmed+El-Shamy). Dr. El-Shamy is the lead author in 10 publications; three of them have been published in the highest journals of liver field (two in Hepatology and one in Journal of Hepatology).

Research Interest: Dr. El-Shamy’s research focuses on investigating the molecular biology underlying the intra- and extra-hepatic pathogenesis of viral hepatitis, including:

  1. Identifying novel Direct Acting Anti-viral molecule against Hepatitis B Virus (HBV), with special focus on eliminating HBV-cccDNA.
  2. Investigating the molecular mechanism underlying the clinical correlation between HBx mutations of HBV and development of liver cancer.
  3. Investigating the molecular mechanism underlying the dysregulation of lipid metabolism after successful cure of Hepatitis C Virus (HCV) by direct acting antiviral therapy (DAA).
  4. Investigating the correlation between HCV infection and B cells disorders, such as Type II Cryoglobulinemia

Course Taught: Advance Topics in Virology

Selected publications (From 26 papers; https://www.ncbi.nlm.nih.gov/pubmed/?term=Ahmed+El-Shamy):

  1. Eng FJ, El-Shamy A, Doyle EH, Klepper AL, Muerhoff S, Branch AD. Newly-discovered Hepatitis C Virus Minicores Circulate in Human Blood. Hepatology Communications. 2017 Nov 12;2(1):21-28.
  2. El-Shamy A, Pendleton M, Eng F, Doyle E, Bashir A and Branch A. Impact of HCV core gene quasispecies on hepatocellular carcinoma risk among HALT-C trial patients. Scientific Reports. 2016; 6:27025. doi: 10.1038/srep27025.
  3. El-Shamy A, Eng FJ, Doyle EH, Klepper AL, Sun X, Sangiovanni A, Iavarone M, Colombo M, Schwartz RE, Hoshida Y, Branch AD. A cell culture system for distinguishing hepatitis C viruses with and without liver cancer-related mutations in the viral core gene. J Hepatol. 2015 Dec;63(6):1323-33.
  4. El-Shamy A, Hotta H. Impact of hepatitis C virus heterogeneity on interferon sensitivity: an overview. World J Gastroenterol. 2014 Jun 28;20(24):7555-69.
  5. El-Shamy A, Shindo M, Shoji I, Deng L, Okuno T, Hotta H. Polymorphisms of the core, NS3, and NS5A proteins of hepatitis C virus genotype 1b associate with development of hepatocellular carcinoma. Hepatology. 2013 Aug;58(2):555-63.
  6. El-Shamy A, Shoji I, El-Akel W, Bilasy SE, Deng L, El-Raziky M, Jiang DP, Esmat G, Hotta H. NS5A sequence heterogeneity of hepatitis C virus genotype 4a predicts clinical outcome of pegylated-interferon-ribavirin therapy in Egyptian patients. J Clin Microbiol. 2012 Dec;50(12):3886-92.
  7. Kim SR, El-Shamy A, Imoto S, Kim KI, Ide YH, Deng L, Shoji I, Tanaka Y, Hasegawa Y, Ota M, Hotta H. Prediction of response to pegylated interferon/ribavirin combination therapy for chronic hepatitis C genotype 1b and high viral load. J Gastroenterol. 2012 Oct;47(10):1143-51.
  8. El-Shamy A, Shoji I, Kim SR, Ide Y, Imoto S, Deng L, Yoon S, Fujisawa T, Tani S, Yano Y, Seo Y, Azuma T, Hotta H. Sequence heterogeneity in NS5A of hepatitis C virus genotypes 2a and 2b and clinical outcome of pegylated-interferon/ribavirin therapy. PLoS One. 2012;7(2):e30513.
  9. El-Shamy A, Kim SR, Ide YH, Sasase N, Imoto S, Deng L, Shoji I, Hotta H. Polymorphisms of hepatitis C virus non-structural protein 5A and core protein and clinical outcome of pegylated interferon/ribavirin combination therapy. Intervirology. 2012;55(1):1-11.
  10. El-Shamy A, Nagano-Fujii M, Sasase N, Imoto S, Kim SR, Hotta H. Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy. Hepatology. 2008 Jul;48(1):38-47.
  11. El-Shamy A, Sasayama M, Nagano-Fujii M, Sasase N, Imoto S, Kim SR, Hotta H. Prediction of efficient virological response to pegylated interferon/ribavirin combination therapy by NS5A sequences of hepatitis C virus and anti-NS5A antibodies in pre-treatment sera. Microbiol Immunol. 2007;51(4):471-82.

Catherine F. Yang, PhDCatherine F. Yang, PhD

Professor of Molecular Pharmacology/Medicinal Chemistry/Biomedical Sciences
Vice President of Academic Affairs
Associate Dean of Medical Education, College of Medicine
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Phone: (916) 686-7300

 

Dr. Yang is a Professor of Molecular Pharmacology at the Department of Basic Science of College of Medicine of California Northstate University (CNU). Before joining CNU, Dr. Yang was a biochemistry/pharmacology Professor in the Department of Chemistry and Biochemistry at Rowan University for 23 years. She also held Professorships at Cooper Medical School of Rowan University in the Departments of Chemistry and Biochemistry and Translational Biomedical Sciences. While at Rowan, Dr. Yang served as the Chairperson for the Department of Chemistry and Biochemistry from 2007 to 2016 and the Director for the Biochemistry Program from 2000 to 2007. She has held research and faculty positions at Harvard Medical School, the American Health Foundation, Boston Biomedical Research Institute, Tokyo University of Medicine and Dentistry, University of Pennsylvania and Zhejiang University of Technology.

Dr. Yang has made strong contributions in elucidating mechanisms of tumor progression, and in the development of novel cancer drugs and antibiotics. She has led research groups studying proteolytic regulatory mechanisms in the advanced stages of prostate cancer, lung cancer and leukemia. Her in-depth research on type 2 diabetic metabolic regulation led to a dual function diabetes drug patent. Dr. Yang’s immunological research resulted in an allergy vaccine development that is currently under clinical trials at affiliated clinics. The specific approach of triggering induction of immunologic tolerance to external or autologous allergens, and induction of sensitization to infectious or tumor antigens, with targeted tissue delivery of particles sized to facilitate uptake by specific cell populations, will provide unique therapeutic platform for curing advancement stage cancer. Dr. Yang’s unique predictive biomarker studies have also spurred a nano-sensor development for an early cancer diagnosis.

Dr. Yang has published more than 60 research papers, several biotechnology books, and is an inventor of several patented inventions. She has also secured numerous grants from the NIH, NSF, Research Corporation and New Jersey Health Foundation as well as funding from many corporations and health foundations. She serves on various review boards of federal, private and health foundation funding agencies.

Research Interests: Dr. Yang research interest centers around the proteolytic regulation in various disease progression stages including aging. Her drug discovery programs specifically target against type 2 diabetes, prostate cancer, leukemia and lung cancer. Her current interest in developing allergy vaccines has been resulted in clinical trials at affiliated clinics.

Selected publications:

  1. Yang, C. F., LI, W., ELLIOTT, R. and Iltchenko, Ni., “Extraction And Purification Of Urushiol From Botanical Sources”, US, Patent, 9,580,373 B2, February 28, 2017.
  2. Lizza, J. R., Patel, S. V., Yang, C. F. and Moura-Letts, G., “Direct Synthesis of Cyanopyrrolidinyl b-Amino Alcohols for the Development of Diabetes Therapeutics”, Eur J Organic Chemistry, 2016, 5160-5168.
  3. Yin, A.C., Goldberg, K.H., Mupparapu, A., Retzbach, E. P., Yin, K., Yang, C. F. and Goldberg, G. S., “Low Molecular Weight Components in Aqueous Echinacea Purpurea Leaf Extract Inhibit Melanoma Cell Growth”, J. Cancer Biology and Therapeutics, 2016, 1(2): 109-117.
  4. Goldberg, K. H., Yin, A.C. Mupparapu, A., Retzbach, E., Goldberg, G. and Yang, C. F., “Components in aquesou Hibiscu rosa-sinensis flower extract inhibit in vitro melanoma cell growth”, J. Trad. Comp. Medicine, 2016, 7(1): 45-49.
  5. Coifman, R. and Yang, C. F., “Method of Depositing Particles of a Substance in a Tissue”, US Patent, US 2015/0140040 A1, May 21, 2015.
  6. Yang, C. F. and Li, W. X, “Novel Dipeptidyl Peptidases IV-based Inhibitors for Type 2 Diabetes Complex with Hypertension”, US, Patent, 9,115,082 B2, Aug. 25, 2015, PCT/US14/12180, 2015.
  7. Yang, C. F., book, “Experiments in Biochemistry and Biotechnology” by Cengage Learning, 2013.
  8. Coifman, R., Yang, C. and Kloske, S., “New Generation of the Poison Ivy Vaccine in Clinical Study”, Garden State Focus, April, 2014, 20, 4, 11-13 (featured on cover page).
  9. Hu, X., Duki, S., Forys, J., Hettinger, J., Buchicchio, J., Dobbins, T. and Yang, C., “Designing Silk-Silk Protein Alloy Materials for Biomedical Applications”, J. Visualized Experiments, 2014
  10. Kojtari, A., Shah, V., Babinec, J.; Yang, C.; Ji, H-F., “Structure-Based Drug Design of Diphenyl α- Aminoalkylphosphonates as Prostate-Specific Antigen Antagonists”, J. of Chem. Information and Modeling, 2014, 54 (10), 2967-2979.
  11. Kojtari, A, Ji, H-F and Yang, C.F. “Aminoalkylphosphoate Derivatives Inhibitors for Prostate Cancer Target”, Provisional US Patent, 13-1627D, 2013, PCT/US15/046528-7014WO(00564).
  12. J. P. Lin and F. Yang, “Recent Advances in Micro/nano- particales for clinical detection of cancer biomarker”, review, Analytical Methods, 2013, 5(21), 5839-6248. (featured on cover page)
  13. Yang, C.F., Zakreski, R., Li, W., Mou, X., Iltchenco, N. and Cooperman, B., “Proteolytic Inhibition in Regulating the Insulin-like Binding Proteins in Prostate Cancer”, Biochem & Physiol., 1(2), 1-8, 2012.
  14. Sun, Y., Yang, C.F. and Li, W., “PROCESS FOR THE PREPARATION OF ERLOTINIB OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS”, US, Patent application #, 61,595,925, 2012.
  15. J. P. Lin, S. H. Li and F. Yang, “Electrochemical Sensors for Cancer Biomarker Detection”, Review, Electroanalysis, 24, 12, 2213-2229, 2012.
  16. Jao, D, Duda, T., Gillespie, A., Yu*, L. and Yang,* C., “Direct Determination of Gold Nanoparticle in Biomacromolecular Matrix with Flame Atomic Absorption Spectrophotometry”, Journal of Nanomedicine and Biotherapeutic Discovery, 2011, 1, 1-5.
  17. Velusamy, V., Arshak, K., Yang, F. C., Korostynska, O. and Adley, C., “Comparison Between DNA Immobilization Techniques on a Redox Polymer Matrix”, Am. J. Ana. Chem., 2011, 2, 392-400.
  18. Wang, H., Xu, X., Li, L., Yang, C. and Ji, H-F., “Optoelectronic property and sensing applications of crystalline nano/microwires of decacyclene”, Micro & Nano Letters, 2011, 6, 9, 763-766.

Simeon Kotchoni, PhDSimeon Kotchoni, PhD

Associate Professor-Molecular Physiology and Biochemistry
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: (916) 686-7690
Fax: (916) 686-8142

 

Research Interest: Dr. Kotchoni is an associate professor in the Department of Pharmaceutical and Biomedical Sciences at California Northstate University, College of Pharmacy (CNUCOP). Prior to joining CNUCOP, he was an assistant Professor at Rutgers University, Camden, New Jersey (2011-2017). He received his B.S. and MS in Biochemistry and Cell Biology from University of Abomey Calavi, Benin, and another MS in Microbiology from Obafemi Awolowo University, Ile-Ife, Nigeria. He received his Ph.D. from the University of Bonn, Germany, where he study the role of Aldehyde Dehydrogenase (ALDH) Gene superfamily in a model plant, Arabidopsis thaliana. After his Ph.D., Dr. Kotchoni has worked as a postdoctoral researcher in Europe (Bonn, Germany), and USA (West Virginia University and Purdue University), using interdisciplinary research techniques, including molecular genetics, cell biology, proteomics, transcriptomics, metabolomics to understand the molecular and cellular mechanisms of growth development and environmental adaptation of organisms.

The Kotchoni laboratory studies health benefits of natural products, especially, medicinal plants, and micororganisms. We focus on understanding the molecular and clinical effects of natural-derived compounds on chronic diseases and developing botanical therapeutics for health promotion and wellness. Our work extends to worldwide research collaborations on drug discovery and development. Drug discovery from natural products represents a re-visited area of active interest. In a multi-disciplinary investigator collaboration, our laboratory is currently developing small molecules from natural products against diabetes, Hepatitis B Virus, prostate, brain, breast and colon cancers with limited or no side effects.

Courses taught: Aromatherapy and Techniques in Metabolomics

Selected Publications (from 104 papers: https://www.researchgate.net/profile/Simeon_Kotchoni)

  1. Missihoun TD, Kotchoni SO., Bartels D. Aldehyde Dehydrogenases Function in the Homeostasis of Pyridine Nucleotides in Arabidopsis thaliana. Nature, Scientific Reports. 2018, 8: 2936. DOI:10.1038/s41598-018-21202-6.
  2. Missihoun TD, Kotchoni SO. Aldehyde dehydrogenases may modulate signaling by lipid peroxidation-derived bioactive aldehydes. Plant Signaling and Behavior. 2017; 12(11): e1387707.
  3. Kotchoni SO., Kibiti C., Gachomo B., Jimenez-Lopez J.C., Martin J.V., Emergence of Herbal Medicine as a New Trend in Pharmacological Management of Diabetes Mellitus. In: Recent Progress in Medicinal Plants. 2017; Chapter 9, pp: 171-188.
  4. Sakirigui A., Gbaguidi F, Kasséhin U.C., Poupaert J., Accrombessi G.C., Kotchoni S.O. Structural and antitrypanosomal data of different carbasones of piperitone. Data in Brief. 2016; 9: 1039-1043.
  5. Kotchoni SO, Gachomo EW, Slobodenko K, Shain DH. AMP DEAMINASE suppression increases biomass, cold tolerance and oil content in green algae. Algal Research. 2016; 16: 473-480.
  6. Missihoun T.D., Kotchoni S.O., Bartels, D. Active site of REDUCED EPIDERMAL FLUORESCENCE 1 (REF1) isoforms contain amino acid substitutions that are different between monocots and dicots. PLOS ONE. 2016; 11(10): e0165867.
  7. Glinma B, Kpoviessi SD, Gbaguidi FA, Kapanda CN, Bero J, Quetin-Leclercq J, Moudachirou M, Poupaert J, Accrombessi GC, Gachomo EW, Baba-Moussa L, Kotchoni SO. Trypanocidal and cytotoxic evaluation of synthesized thiosemicarbazones as potential drug leads against sleeping sickness. Molecular Biology Reports. 2014; 41(3): 1617-1622.
  8. Jimenez-Lopez JC, Wang X, Kotchoni SO, Huang S, Szymanski DB, Staiger CJ., Heterodimeric capping protein from Arabidopsis is membrane-associated, actin-binding protein. Plant Physiology. 2014; 166: 1312-1328.
  9. Gbenou J. D., Ahounou J.F., Akakpo H. B., Yayi E., Laleye A., Gbaguidi F., Baba-Moussa L., Darboux R., Dansou P., Moudachirou M., Kotchoni S.O. Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats. Molecular Biology Reports. 2013; 40(2): 1127-1134.
  10. Jimenez-Lopez JC, Kotchoni SO, Hernandez-Soriano MC, Gachomo EW, Alché JD. Structural functionality, catalytic mechanism modeling and molecular allergenicity of phenylcoumaran benzylic ether reductase, an olive pollen (Ole e 12) allergen. Journal of Computational Aided Molecular Design. 2013; 27: 873-895.
  11. Jimenez-Lopez J.C., Gachomo E.W., Ariyo O.A., Baba-Moussa L., Kotchoni S.O. Specific conformational epitope features of pathogenesis-related proteins mediating cross-reactivity between pollen and food allergens. Molecular Biology Reports. 2012; 39(1): 123-130.
  12. Jimenez-Lopez J.C., Kotchoni S.O., Rodríguez-García M.I., Alché J.D. Structure and functional features of olive pollen pectin methylesterase using homology modeling and molecular docking methods. Journal of Molecular Modeling. 2012; 18(12): 4965-4984
  13. Jimenez-Lopez J.C., Gachomo E.W., Ariyo O.A., Baba-Moussa L. and Kotchoni S.O. Specific conformational epitope features of pathogenesis-related proteins mediating cross-reactivity between pollen and food allergens. Molecular Biology Reports. 2012; 39(1): 123-130.
  14. Baba-Moussa L., Sina H., Scheftel J.M., Moreau B., Sainte-Marie D., Kotchoni S.O., Prévost G., Couppié P. Staphylococcal Panton-Valentine leucocidin as a major virulence factor associated to furuncles. PLoS One. 2011; 6(10): e25716.
  15. Kotchoni S.O., Jimenez-Lopez J.C., Gachomo E.W. Seufferheld M.J., A new and unified nomenclature for male fertility restorer (RF) proteins in higher plants. PLOS ONE. 2010; 5(12): e15906.
  16. Zhang C., Kotchoni S.O., Samuels L., Szymanski D.B., SPIKE1 signals originate from and assemble specialized domains of the endoplasmic reticulum. Current Biology. 2010; 20(23): 2144-2149.
  17. Kotchoni S.O., Zakharova T., Mallery E.L., El-Din El-Assal S., Le J., Szymanski D.B., The association of the Arabidopsis actin-related protein (ARP) 2/3 complex with cell membranes is linked to its assembly status, but not to its activation. Plant Physiology. 2009; 151(4): 2095-2109.

Hongbin Wang, PharmBS, MS, PhDHongbin Wang, PharmBS, MS, PhD

Assistant Professor-Pharmacology
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Telephone: (916) 686-8034
Fax: (916) 686-8142

 

Research Interest: Dr. Hongbin Wang is an Assistant Professor in the Department of Pharmaceutical and Biomedical Sciences at the California Northstate University College of Pharmacy. Before joining CNUCOP, he worked as a Senior Research Investigator in the Department of Pathology & Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. He received his B. Med. (Pharmacy) and M. Med. (Pharmacology) from Second Military Medical University (Shanghai, China), and his Ph.D. in Pharmacology from University of Pennsylvania.

His primary research interests include studying: 1), interaction of complement activation fragment C4a with protease-activated receptor (PAR) 1/4 G-protein coupled receptors and their roles and signaling pathways in the initiation and progress of sepsis, diabetes mellitus, and autoimmune diseases. 2), the function and regulation of protein kinase C isozymes (PKCs), the receptors for the phorbol ester tumor promoters and the second messenger diacylglycerol (DAG), an important intracellular mediator of proliferation and malignant transformation. 3), the “chimaerins”, novel phorbol ester/DAG receptors with Rac-GAP activity toward Rac that is a small GTP-binding protein that regulates actin cytoskeleton organization, cell cycle progression, gene expression, cell adhesion and migration.

Publications (selected from 44 papers):

  1. Wang H, Daniel Ricklin, and John D. Lambris. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A. 2017; 114(41): 10948-10953. PMID: 28973891
  2. Wang H, Gutierrez-Uzquiza A, Garg R, Barrio-Real L, Abera MB, Lopez-Haber C, Rosemblit C, Lu H, Abba M, Kazanietz MG. Transcriptional Regulation of Oncogenic Protein Kinase C Epsilon (PKCe) by Stat1 and Sp1. J Biol Chem. 2014; 289(28): 19823-38. PMID: 24825907
  3. Wang H*, Xiao L and Kazanietz MG*. Tmp21/p23, an ER/Golgi cargo protein, regulates phorbol ester-induced apoptosis in LNCaP prostate cancer cells via direct association with PKCd. J Biol Chem. 2011; 286:15821-15831. PMID: 21454541. (*Corresponding author).
  4. Wang H, Kazanietz MG. p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains. Mol Biol Cell. 2010; 21:1398-1408. PMID: 20164256
  5. Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, and Kazanietz MG. Phospholipase Cg/Diacylglycerol-dependent Activation of b2-Chimaerin Restricts EGF-Induced Rac Signaling. EMBO J. 2006; 25: 2062-2074. PMID: 16628218
  6. Wang H, and Kazanietz MG. The lipid second messenger diacylglycerol as a negative regulator of Rac signaling. Biochem Soc Trans. 2006; 34: 860-862. PMID: 17052214
  7. Caloca MJ*, Wang H*, Kazanietz MG. Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a ‘non-protein kinase C’ phorbol ester receptor. Biochem J. 2003; 375: 313-321 (* Equal contribution). PMID: 12877655
  8. Wang H, Kazanietz MG. Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. J Biol Chem. 2002; 277: 4541-4550. PMID: 1168955
  9. Rachana Garg, Lorena Benedetti, Mahlet Abera, HongBin Wang, Martin Abba, and Marcelo Kazanietz. Protein kinase C and cancer: what we know and what we do not. Oncogene 2013; PMID: 24336328
  10. Oxana M. Tsygankova, HongBin Wang, and Judy L. Meinkoth. RAP1GAP regulates tumor cell migration and invasion. J Biol Chem. 2013; 288:24636-46. PMID: 23864657
  11. Alvaro Gutierrez-Uzquiza, Francheska Colon-Gonzalez, Thomas A. Leonard, Bertram J. Canagarajah, HongBin Wang, Bruce J. Mayer, James H. Hurley, and Marcelo G. Kazanietz. Coordinated activation of the Rac-GAP (b2-chimaerin) by an atypical proline-rich domain and diacylglycerol. Nature Commun. 2013; 4:1849. PMID: 23673634
  12. Garg R, Blando J, Perez CJ, Wang H, Benavides FJ, Kazanietz MG. Activation of Nuclear Factor-Kappa B (NFκB) in Prostate Cancer is Mediated by PKC Epsilon (PKC{epsilon}). J. Biol. Chem. 2012; 287:37570-82. PMID: 22955280
  13. Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL. The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus. Cell. 2012; 149:1594-606. PMID: 22726444
  14. Maria Soledad Sosa, Cynthia Lopez-Haber, Chengfeng Yang, Hongbin Wang, Mark A. Lemmon, John M. Busillo, Jiansong Luo, Jeffrey L. Benovic, Andres Klein-Szanto, Hiroshi Yagi, J. Silvio Gutkind, Ramon E. Parsons, and Marcelo G. Kazanietz. Identification of the Rac-GEF-P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell. 2010; 40:877-892. PMID: 21172654
  15. Oxana M. Tsygankova, Gregory V. Prendergast, Kanchan Puttaswamy, Yan Wang, Michael D. Feldman, Hongbin Wang, Marcia S. Brose and Judy L. Meinkoth. Downregulation of Rap1GAP contributes to Ras transformation. Mol. Cell. Biol. 2007; 27: 6647-6658. PMID: 17646383
  16. Leskow FC, Holloway BA, Wang H, Mullins MC, Kazanietz MG. The zebrafish homologue of mammalian chimaerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci U S A. 2006; 103: 5373-5378. PMID: 16569702
  17. Zhang Z, Kostetskii I, Moss SB, Jones BH, Ho C, Wang H, Kishida T, Gerton GL, Radice GL, Strauss JF 3rd. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Proc Natl Acad Sci U S A. 2004; 101: 12946-12951. PMID: 15328412