Hongbin Wang, PharmBS, MS, PhD

Hongbin Wang, PharmBS, MS, PhD

Department of Pharmaceutical and Biomedical Sciences
Assistant Professor-Pharmacology

Phone: (916) 686-8034
Fax: (916) 686-8142
Hongbin.Wang@cnsu.edu

About

Dr. Hongbin Wang is an Assistant Professor in the Department of Pharmaceutical and Biomedical Sciences at the California Northstate University College of Pharmacy. Before joining CNUCOP, he worked as a Senior Research Investigator in the Department of Pathology & Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. He received his B. Med. (Pharmacy) and M. Med. (Pharmacology) from Second Military Medical University (Shanghai, China), and his Ph.D. in Pharmacology from University of Pennsylvania.

His primary research interests include studying: 1), interaction of complement activation fragment C4a with protease-activated receptor (PAR) 1/4 G-protein coupled receptors and their roles and signaling pathways in the initiation and progress of sepsis, diabetes mellitus, and autoimmune diseases. 2), the function and regulation of protein kinase C isozymes (PKCs), the receptors for the phorbol ester tumor promoters and the second messenger diacylglycerol (DAG), an important intracellular mediator of proliferation and malignant transformation. 3), the "chimaerins", novel phorbol ester/DAG receptors with Rac-GAP activity toward Rac that is a small GTP-binding protein that regulates actin cytoskeleton organization, cell cycle progression, gene expression, cell adhesion and migration.

Scholarship

Publications (selected from 44 papers. h index=16)

  • Wang H, Daniel Ricklin, and John D. Lambris. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A. 2017; 114(41): 10948-10953. PMID: 28973891
  • Wang H, Gutierrez-Uzquiza A, Garg R, Barrio-Real L, Abera MB, Lopez-Haber C, Rosemblit C, Lu H, Abba M, Kazanietz MG. Transcriptional Regulation of Oncogenic Protein Kinase C Epsilon (PKC) by Stat1 and Sp1. J Biol Chem. 2014; 289(28): 19823-38. PMID: 24825907
  • Wang H*, Xiao L and Kazanietz MG*. Tmp21/p23, an ER/Golgi cargo protein, regulates phorbol ester-induced apoptosis in LNCaP prostate cancer cells via direct association with PKC J Biol Chem. 2011; 286:15821-15831. PMID: 21454541. (*Corresponding author).
  • Wang H, Kazanietz MG. p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains. Mol Biol Cell. 2010; 21:1398-1408. PMID: 20164256
  • Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, and Kazanietz MG. Phospholipase C/Diacylglycerol-dependent Activation of 2-Chimaerin Restricts EGF-Induced Rac Signaling. EMBO J. 2006; 25: 2062-2074. PMID: 16628218
  • Wang H, and Kazanietz MG. The lipid second messenger diacylglycerol as a negative regulator of Rac signaling. Biochem Soc Trans. 2006; 34: 860-862. PMID: 17052214
  • Caloca MJ*, Wang H*, Kazanietz MG. Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor. Biochem J. 2003; 375: 313-321 (* Equal contribution). PMID: 12877655
  • Wang H, Kazanietz MG. Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. J Biol Chem. 2002; 277: 4541-4550. PMID: 1168955
  • Rachana Garg, Lorena Benedetti, Mahlet Abera, HongBin Wang, Martin Abba, and Marcelo Kazanietz. Protein kinase C and cancer: what we know and what we do not. Oncogene 2013; PMID: 24336328
  • Oxana M. Tsygankova, HongBin Wang, and Judy L. Meinkoth. RAP1GAP regulates tumor cell migration and invasion. J Biol Chem. 2013; 288:24636-46. PMID: 23864657
  • Alvaro Gutierrez-Uzquiza, Francheska Colon-Gonzalez, Thomas A. Leonard, Bertram J. Canagarajah, HongBin Wang, Bruce J. Mayer, James H. Hurley, and Marcelo G. Kazanietz. Coordinated activation of the Rac-GAP (2-chimaerin) by an atypical proline-rich domain and diacylglycerol. Nature Commun. 2013; 4:1849. PMID: 23673634
  • Garg R, Blando J, Perez CJ, Wang H, Benavides FJ, Kazanietz MG. Activation of Nuclear Factor-Kappa B (NFκB) in Prostate Cancer is Mediated by PKC Epsilon (PKC{epsilon}). J. Biol. Chem. 2012; 287:37570-82. PMID: 22955280
  • Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL. The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus. Cell. 2012; 149:1594-606. PMID: 22726444
  • Maria Soledad Sosa, Cynthia Lopez-Haber, Chengfeng Yang, Hongbin Wang, Mark A. Lemmon, John M. Busillo, Jiansong Luo, Jeffrey L. Benovic, Andres Klein-Szanto, Hiroshi Yagi, J. Silvio Gutkind, Ramon E. Parsons, and Marcelo G. Kazanietz. Identification of the Rac-GEF-P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell. 2010; 40:877-892. PMID: 21172654
  • Oxana M. Tsygankova, Gregory V. Prendergast, Kanchan Puttaswamy, Yan Wang, Michael D. Feldman, Hongbin Wang, Marcia S. Brose and Judy L. Meinkoth. Downregulation of Rap1GAP contributes to Ras transformation. Mol. Cell. Biol. 2007; 27: 6647-6658. PMID: 17646383
  • Leskow FC, Holloway BA, Wang H, Mullins MC, Kazanietz MG. The zebrafish homologue of mammalian chimaerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci U S A. 2006; 103: 5373-5378. PMID: 16569702
  • Zhang Z, Kostetskii I, Moss SB, Jones BH, Ho C, Wang H, Kishida T, Gerton GL, Radice GL, Strauss JF 3rd. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Proc Natl Acad Sci U S A. 2004; 101: 12946-12951. PMID: 15328412

Accomplishments and Awards

  • Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Postdoctoral Research Training Grants (T32) (2006-2009). Total support ~$160,000.